Cooperative, Heparan Sulfate-Dependent Cellular Uptake of Dimeric Guanidinoglycosides
نویسندگان
چکیده
منابع مشابه
Cellular uptake of unconjugated TAT peptide involves clathrin-dependent endocytosis and heparan sulfate receptors.
Delivery of macromolecules mediated by protein transduction domains (PTDs) attracts a lot of interest due to its therapeutic and biotechnological potential. A major reevaluation of the mechanism of PTD-mediated internalization and the role of endocytosis in this mechanism has been recently initiated. Here, we demonstrate that the entry of TAT peptide (one of the most widely used PTDs) into diff...
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ژورنال
عنوان ژورنال: ChemBioChem
سال: 2010
ISSN: 1439-4227
DOI: 10.1002/cbic.201000399